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1

The IL-6/sIL-6R complex as a novel target for therapeutic approaches

Rose-John, Stefan, Waetzig, Georg H, Scheller, Jürgen, Grötzinger, Joachim, Seegert, Dirk

Journal:

Expert Opinion on Therapeutic Targets

Year:

2007

Language:

english

File:

PDF, 377 KB

english, 2007

2

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

Lokau, Juliane, Nitz, Rebecca, Agthe, Maria, Monhasery, Niloufar, Aparicio-Siegmund, Samadhi, Schumacher, Neele, Wolf, Janina, Möller-Hackbarth, Katja, Waetzig, Georg H., Grötzinger, Joachim, Müller-N

Journal:

Year:

2016

Language:

english

File:

PDF, 3.87 MB

english, 2016

3

The balance of Interleukin (IL)-6, IL-6:soluble IL-6 receptor (IL-6R) and IL-6:sIL-6R:sgp130 complexes allows simultaneous classic and trans-signaling

Baran, Paul, Hansen, Selina, Waetzig, Georg H., Akbarzadeh, Mohammad, Lamertz, Larissa, Huber, Heinrich J., Ahmadian, M. Reza, Moll, Jens M., Scheller, Jürgen

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 2.89 MB

english, 2018

4

Genetic variation in DLG5 is associated with inflammatory bowel disease

Stoll, Monika, Corneliussen, Brit, Costello, Christine M, Waetzig, Georg H, Mellgard, Bjorn, Koch, W Andreas, Rosenstiel, Philip, Albrecht, Mario, Croucher, Peter J P, Seegert, Dirk

Journal:

Nature Genetics

Year:

2004

Language:

english

File:

PDF, 184 KB

english, 2004

5

Mechanisms of infliximab. The reverse side of a drug effect

Georg H. Waetzig, Stefan Schreiber

Journal:

Inflammatory Bowel Diseases

Year:

2004

Language:

english

File:

PDF, 153 KB

english, 2004

6

Efficient regeneration ofSphagnum fallaxfrom isolated protoplasts

Amla Batra, Horst Binding, Susanne Rasmussen, Hansjörg Rudolph, Georg H. Waetzig

Journal:

In Vitro Cellular & Developmental Biology - Plant

Year:

2003

Language:

english

File:

PDF, 147 KB

english, 2003

7

The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution

Inken Lorenzen, Weifeng Shang, Markus Perbandt, Maxim V. Petoukhov, Dmitri I. Svergun, Georg H. Waetzig, Stefan Rose-John, Rolf Hilgenfeld, Joachim Grötzinger

Journal:

European Journal of Cell Biology

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

8

Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling

Sven Malchow, Wolfgang Thaiss, Nathalie Jänner, Georg H. Waetzig, Jessica Gewiese-Rabsch, Christoph Garbers, Kosuke Yamamoto, Stefan Rose-John, Jürgen Scheller

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2011

Language:

english

File:

PDF, 2.23 MB

english, 2011

9

124 IL6/sIL6R-Transsignaling Controls Innate and Aquired Immunity

B. Rabe, Athena Chalaris, Ulrike May, Krzysztof Paliga, Hans Lange, Tamas Laskay, Ceri A. Fielding, Georg H. Waetzig, Dirk Seegert, Anwen S. Williams, Simon A. Jones, Stefan Rose-John, J. Scheller

Journal:

Year:

2007

Language:

english

File:

PDF, 46 KB

english, 2007

10

152 Characterization of Mutants of the Soluble GP130 Protein in Terms of their Binding Affinity Against the IL6/SIL6R Complex

Stephanie Tenhumberg, Georg H. Waetzig, Dirk Seegert, Jürgen Scheller, Joachim Grötzinger, Stefan Rose-John

Journal:

Year:

2007

Language:

english

File:

PDF, 50 KB

english, 2007

11

32 The role of IL6-transsignaling in acute and chronic inflammation

B. Rabe, Athena Chalaris, Nina Adam, Krzysztof Paliga, Hans Lange, Tamas Laskay, Ceri A. Fielding, Georg H. Waetzig, Dirk Seegert, Anwen S. Williams, Simon A. Jones, Christian Sina, Stefan Rose-John,

Journal:

Year:

2008

Language:

english

File:

PDF, 47 KB

english, 2008

12

227 Design of high affinity interleukin-6 and gp130 variants: Implications for cytokine-receptor assembly

Nina Adam, Stephanie Tenhumberg, Georg H. Waetzig, Athena Chalaris, Björn Rabe, Jan Suthaus, Dirk Seegert, Jürgen Scheller, Stefan Rose-John, Joachim Grötzinger

Journal:

Year:

2008

Language:

english

File:

PDF, 45 KB

english, 2008

13

PL4-5 Blockade of IL-6 signaling via soluble IL-6R is superior to global IL-6 blockade by antibodies in models of inflammation and septic shock

Stefan Rose-John, Tanja Barkhausen, Nina Adam, Athena Chalaris, Georg Waetzig, Jürgen Scheller

Journal:

Year:

2010

Language:

english

File:

PDF, 136 KB

english, 2010

14

CS11-5. Inhibition of Interleukin 6 classic signaling is a novel function of soluble gp130 which is controlled by the ratio of Interleukin 6 and soluble Interleukin 6 receptor

Christoph Garbers, Wolfgang Thaiss, Georg H. Waetzig, Gareth W. Jones, Doreen M. Floss, Inken Lorenzen, Joachim Grötzinger, Simon A. Jones, Stefan Rose-John, Jürgen Scheller

Journal:

Year:

2011

Language:

english

File:

PDF, 140 KB

english, 2011

15

Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis

Jan Sodenkamp, Georg H. Waetzig, Jürgen Scheller, Dirk Seegert, Joachim Grötzinger, Stefan Rose-John, Stefan Ehlers, Christoph Hölscher

Journal:

Year:

2012

Language:

english

File:

PDF, 2.80 MB

english, 2012

16

Identification of structural traits that increase the antimicrobial activity of a chimeric peptide of human β-defensins 2 and 3

Björn Spudy, Frank D. Sönnichsen, Georg H. Waetzig, Joachim Grötzinger, Sascha Jung

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 450 KB

english, 2012

17

Differential p38 mitogen-activated protein kinase target phosphorylation in responders and nonresponders to infliximab

Georg H Waetzig, Philip Rosenstiel, Susanna Nikolaus, Dirk Seegert, Stefan Schreiber

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 137 KB

english, 2003

18

TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells

Philip Rosenstiel, Massimo Fantini, Karen Braeutigam, Georg Waetzig, Tanja Kuehbacher, Dirk Seegert, Stefan Schreiber

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 169 KB

english, 2003

19

TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells

Philip Rosenstiel, Massimo Fantini, Karen Bräutigam, Tanja Kühbacher, Georg H. Waetzig, Dirk Seegert, Stefan Schreiber

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 281 KB

english, 2003

20

Su1079 Tryptophan Deficiency in Crohn Disease

Nikolaus, Susanna, Al-Massad, Natalie, Bethge, Johannes, Waetzig, Georg H., Rosenstiel, Philip C., Junker, Ralf, Thieme, Florian, Schreiber, Stefan

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 309 KB

english, 2014

21

Mo1777 Identification of p22phox as a Novel Functional Interaction Partner of NOD2

Lipinski, Simone, Hüttmann, Agnes, Waetzig, Georg H., Haesler, Robert, Schreiber, Stefan, Rosenstiel, Philip C.

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 73 KB

english, 2012

22

Differential activity and expression of mitogen-activated protein kinases in inflammatory bowel disease

Waetzig, Georg H., Seegert, Dirk, Nikolaus, Susanna, Rosenstiel, Philip, Sfikas, Nikolaos, Schreiber, Stefan

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 189 KB

english, 2001

23

Efficient Regeneration of Sphagnum fallax from Isolated Protoplasts

Amla Batra, Horst Binding, Susanne Rasmussen, Hansjörg Rudolph and Georg H. Waetzig

Journal:

In Vitro Cellular & Developmental Biology - Plant

Year:

2003

Language:

english

File:

PDF, 431 KB

english, 2003

24

Interleukin-6: a villain in the drama of pancreatic cancer development and progression

Holmer, Reinhild, Goumas, Freya A, Waetzig, Georg H, Rose-John, Stefan, Kalthoff, Holger

Journal:

Hepatobiliary & Pancreatic Diseases International

Year:

2014

Language:

english

File:

PDF, 3.75 MB

english, 2014

25

Hitting a complex target: an update on interleukin-6 trans-signalling

Waetzig, Georg H, Rose-John, Stefan

Journal:

Expert Opinion on Therapeutic Targets

Year:

2012

Language:

english

File:

PDF, 320 KB

english, 2012

26

A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor

Düsterhöft, Stefan, Höbel, Katharina, Oldefest, Mirja, Lokau, Juliane, Waetzig, Georg H., Chalaris, Athena, Garbers, Christoph, Scheller, Jürgen, Rose-John, Stefan, Lorenzen, Inken, Grötzinger, Joachi

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 2.23 MB

english, 2014

27

Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays

Costello, Christine M., Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H., Hahn, Andreas, Lu, Tim, Gurbuz, Yesim, Nikolaus, Susanna, Albrecht, Mario, Hampe, Jochen, Lucius, Ralph, Klöp

Journal:

Year:

2005

Language:

english

File:

PDF, 777 KB

english, 2005

28

RAID3 - An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity

Mittelberger, Florian, Meyer, Cindy, Waetzig, Georg H, Zacharias, Martin, Valentini, Erica, Svergun, Dmitri I, Berg, Katharina, Lorenzen, Inken, Grötzinger, Joachim, Rose-John, Stefan, Hahn, Ulrich

Journal:

Year:

2015

Language:

english

File:

PDF, 882 KB

english, 2015

29

Localization of hydrogen peroxide during the defence response of Arabidopsis thaliana against the plant-parasitic nematode Heterodera glycines

Waetzig, Georg, Grundler, Florian, Sobczak, Miroslaw

Journal:

Year:

1999

Language:

english

File:

PDF, 1.17 MB

english, 1999

30

A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide-bridge resulting from alternative mRNA splicing

Wolf, Janina, Waetzig, Georg H., Reinheimer, Torsten M., Scheller, Jürgen, Rose-John, Stefan, Garbers, Christoph

Journal:

Biochemical and Biophysical Research Communications

Year:

2016

Language:

english

File:

PDF, 1.01 MB

english, 2016

31

ID: 193

Lokau, Juliane, Aghte, Maria, Waetzig, Georg H., Rose-John, Stefan, Garbers, Christoph

Journal:

Year:

2015

Language:

english

File:

PDF, 46 KB

english, 2015

32

Different soluble forms of the interleukin-6 family signal transducer gp130 fine-tune the blockade of interleukin-6 trans-signaling

Wolf, Janina, Waetzig, Georg H., Chalaris, Athena, Reinheimer, Torsten M., Wege, Henning, Rose-John, Stefan, Garbers, Christoph

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 973 KB

english, 2016

33

Constitutively Active Mutant gp130 Receptor Protein from Inflammatory Hepatocellular Adenoma Is Inhibited by an Anti-gp130 Antibody That Specifically Neutralizes Interleukin 11 Signaling

Sommer, Jan, Effenberger, Timo, Volpi, Elena, Waetzig, Georg H., Bernhardt, Marten, Suthaus, Jan, Garbers, Christoph, Rose-John, Stefan, Floss, Doreen M., Scheller, Jürgen

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 2.03 MB

english, 2012

34

Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection

Ott, Stephan J., Waetzig, Georg H., Rehman, Ateequr, Moltzau-Anderson, Jacqueline, Bharti, Richa, Grasis, Juris A., Cassidy, Liam, Tholey, Andreas, Fickenscher, Helmut, Seegert, Dirk, Rosenstiel, Phil

Journal:

Gastroenterology

Year:

2016

Language:

english

File:

PDF, 8.46 MB

english, 2016

35

Distinct effects of interleukin-6 classic and trans-signaling in bone fracture healing

Prystaz, Katja, Kaiser, Kathrin, Kovtun, Anna, Haffner-Luntzer, Melanie, Fischer, Verena, Rapp, Anna E., Liedert, Astrid, Strauss, Gudrun, Waetzig, Georg H., Rose-John, Stefan, Ignatius, Anita

Journal:

The American Journal of Pathology

Year:

2017

Language:

english

File:

PDF, 2.29 MB

english, 2017

36

Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma

Kaiser, Kathrin, Prystaz, Katja, Vikman, Anna, Haffner-Luntzer, Melanie, Bergdolt, Stephanie, Strauss, Gudrun, Waetzig, Georg H., Rose-John, Stefan, Ignatius, Anita

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2018

Language:

english

File:

PDF, 12.78 MB

english, 2018

37

Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases

Nikolaus, Susanna, Waetzig, Georg H., Butzin, Sven, Ziolkiewicz, Monika, Al-Massad, Natalie, Thieme, Florian, Lövgren, Ulf, Rasmussen, Birgitte B., Reinheimer, Torsten M., Seegert, Dirk, Rosenstiel, P

Journal:

International Journal of Colorectal Disease

Year:

2018

Language:

english

File:

PDF, 1.57 MB

english, 2018

38

Reply

Schreiber, Stefan, Nikolaus, Susanna, Waetzig, Georg H., Rosenstiel, Philip

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 236 KB

english, 2018

39

Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses

Lamertz, Larissa, Rummel, Franziska, Polz, Robin, Baran, Paul, Hansen, Selina, Waetzig, Georg H., Moll, Jens M., Floss, Doreen M., Scheller, Jürgen

Journal:

Science Signaling

Year:

2018

Language:

english

File:

PDF, 2.15 MB

english, 2018

40

Adjustment of triple shellac coating for precise release of bioactive substances with different physico-chemical properties in the ileocolonic region

Theismann, Eva-Maria, Katharina Keppler, Julia, Knipp, Jörg-Rainer, Fangmann, Daniela, Appel, Esther, Gorb, Stanislav N., Waetzig, Georg H., Schreiber, Stefan, Laudes, Matthias, Schwarz, Karin

Journal:

International Journal of Pharmaceutics

Year:

2019

File:

PDF, 1.73 MB

2019

41

Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells

Lokau, Juliane, Kleinegger, Florian, Garbers, Yvonne, Waetzig, Georg H., GrÃ¶tzinger, Joachim, Rose-John, Stefan, Haybaeck, Johannes, Garbers, Christoph, Spencer, Juliet V

Journal:

Year:

2020

File:

PDF, 1.76 MB

2020

42

Non-specific effects resulting from use of tocilizumab in mice

Lokau, Juliane, Waetzig, Georg H., Rose-John, Stefan, Garbers, Christoph

Journal:

Year:

2020

File:

PDF, 685 KB

2020

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